1rk8

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{{STRUCTURE_1rk8| PDB=1rk8 | SCENE= }}
{{STRUCTURE_1rk8| PDB=1rk8 | SCENE= }}
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'''Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex'''
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===Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex===
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==Overview==
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The exon junction complex (EJC) is deposited on mRNAs as a consequence of splicing and influences postsplicing mRNA metabolism. The Mago-Y14 heterodimer is a core component of the EJC. Recently, the protein PYM has been identified as an interacting partner of Mago-Y14. Here we show that PYM is a cytoplasmic RNA-binding protein that is excluded from the nucleus by Crm1. PYM interacts directly with Mago-Y14 by means of its N-terminal domain. The crystal structure of the Drosophila ternary complex at 1.9 A resolution reveals that PYM binds Mago and Y14 simultaneously, capping their heterodimerization interface at conserved surface residues. Formation of this ternary complex is also observed with the human proteins. Mago residues involved in the interaction with PYM have been implicated in nonsense-mediated mRNA decay (NMD). Consistently, human PYM is active in NMD tethering assays. Together, these data suggest a role for PYM in NMD.
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(as it appears on PubMed at http://www.pubmed.gov), where 14968132 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14968132}}
==About this Structure==
==About this Structure==
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[[Category: Rbd]]
[[Category: Rbd]]
[[Category: Rrm]]
[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:35:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:45:21 2008''

Revision as of 06:45, 29 July 2008

Image:1rk8.png

Template:STRUCTURE 1rk8

Structure of the cytosolic protein PYM bound to the Mago-Y14 core of the exon junction complex

Template:ABSTRACT PUBMED 14968132

About this Structure

1RK8 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex., Bono F, Ebert J, Unterholzner L, Guttler T, Izaurralde E, Conti E, EMBO Rep. 2004 Mar;5(3):304-10. Epub 2004 Feb 13. PMID:14968132

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