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1okq

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[[Image:1okq.jpg|left|200px]]
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{{Seed}}
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[[Image:1okq.png|left|200px]]
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{{STRUCTURE_1okq| PDB=1okq | SCENE= }}
{{STRUCTURE_1okq| PDB=1okq | SCENE= }}
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'''LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR, CA1 SITE MUTANT'''
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===LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR, CA1 SITE MUTANT===
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==Overview==
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Laminin-2 (alpha2beta1gamma1) is found in basement membranes surrounding muscle and peripheral nerve cells. Several types of cellular receptors bind to the laminin G-like (LG) domains at the C terminus of the alpha2 chain, the interaction with alpha-dystroglycan (alpha-DG) being particularly important in muscle. We have used site-directed mutagenesis and in vitro binding assays to map the binding sites on the laminin alpha2 chain LG4-LG5 domain pair for alpha-DG, heparin and sulfatides. Calcium-dependent alpha-DG recognition requires the calcium ion in LG4, but not the one in LG5, as well as basic residues in both LG domains. Heparin and sulfatides also bind to basic residues in both LG domains, but there is little overlap in the binding sites for alpha-DG and heparin/sulfatides. The results should prove useful for the molecular dissection of laminin-receptor interactions in vivo.
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The line below this paragraph, {{ABSTRACT_PUBMED_12963372}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12963372 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12963372}}
==About this Structure==
==About this Structure==
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[[Category: Laminin]]
[[Category: Laminin]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:58:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:45:54 2008''

Revision as of 06:45, 29 July 2008

Image:1okq.png

Template:STRUCTURE 1okq

LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR, CA1 SITE MUTANT

Template:ABSTRACT PUBMED 12963372

About this Structure

1OKQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair., Wizemann H, Garbe JH, Friedrich MV, Timpl R, Sasaki T, Hohenester E, J Mol Biol. 2003 Sep 19;332(3):635-42. PMID:12963372

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