2b52

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[[Image:2b52.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2b52| PDB=2b52 | SCENE= }}
{{STRUCTURE_2b52| PDB=2b52 | SCENE= }}
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'''Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562'''
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===Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562===
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==Overview==
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New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.
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The line below this paragraph, {{ABSTRACT_PUBMED_14698155}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14698155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14698155}}
==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Protein kinase]]
[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:51:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:48:41 2008''

Revision as of 06:48, 29 July 2008

Template:STRUCTURE 2b52

Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562

Template:ABSTRACT PUBMED 14698155

About this Structure

2B52 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3., Yue EW, DiMeo SV, Higley CA, Markwalder JA, Burton CR, Benfield PA, Grafstrom RH, Cox S, Muckelbauer JK, Smallwood AM, Chen H, Chang CH, Trainor GL, Seitz SP, Bioorg Med Chem Lett. 2004 Jan 19;14(2):343-6. PMID:14698155

Page seeded by OCA on Tue Jul 29 09:48:41 2008

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