1wks

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[[Image:1wks.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1wks| PDB=1wks | SCENE= }}
{{STRUCTURE_1wks| PDB=1wks | SCENE= }}
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'''Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2'''
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===Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2===
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==Overview==
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The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3' tail containing a stem-loop that is critical for their retrotransposition. Presumably, the first step of retrotransposition is the recognition of their 3' tails by UnaL2-encoded reverse transcriptase. The solution structure of a 17-nucleotide RNA derived from the 3' tail of UnaL2 was determined by NMR. The GGAUA loop forms a specific structure in which the uridine is exposed to solvent with the third and fifth adenosines stacked. A sharp turn in the phosphodiester backbone occurs between the second guanosine and third adenosine. When the uridine is mutated (but not deleted), all mutants form the loop structure, indicating that the loop structure requires an exposed fourth residue. The retrotransposition assay in HeLa cells revealed that retrotransposition requires the second guanosine, although any nucleoside functions at the fourth position, suggesting that UnaL2 reverse transcriptase specifically recognizes the 5' side of the GGANA loop.
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The line below this paragraph, {{ABSTRACT_PUBMED_15273327}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15273327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15273327}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKS OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKS OCA].
==Reference==
==Reference==
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[[Category: Retrotransposition]]
[[Category: Retrotransposition]]
[[Category: Rna]]
[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:49:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:52:43 2008''

Revision as of 06:52, 29 July 2008

Image:1wks.png

Template:STRUCTURE 1wks

Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2

Template:ABSTRACT PUBMED 15273327

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of an RNA stem-loop derived from the 3' conserved region of eel LINE UnaL2., Baba S, Kajikawa M, Okada N, Kawai G, RNA. 2004 Sep;10(9):1380-7. Epub 2004 Jul 23. PMID:15273327

Page seeded by OCA on Tue Jul 29 09:52:43 2008

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