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1tjz

From Proteopedia

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[[Image:1tjz.gif|left|200px]]
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{{STRUCTURE_1tjz| PDB=1tjz | SCENE= }}
{{STRUCTURE_1tjz| PDB=1tjz | SCENE= }}
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'''Solution Structure of the Active Site Stem-Loop of the VS Ribozyme'''
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===Solution Structure of the Active Site Stem-Loop of the VS Ribozyme===
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==Overview==
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The VS ribozyme is the largest ribozyme in its class and is also the least structurally characterized thus far. The current working model of the VS ribozyme locates the active site in stem-loop VI. The solution structure of this active site loop was determined using high resolution NMR spectroscopy. The structure reveals that the ground-state conformation of the active site differs significantly from that determined previously from chemical structure probing and mutational analysis of the ribozyme in its active conformation, which contains several looped out bases. In contrast, the base-pairing scheme found for the isolated loop contains three mismatched base-pairs: an A+-C, a G-U wobble, and a sheared G-A base-pair and no looped out bases. Dynamics observed within the active site loop provide insight into the mechanism by which the RNA can rearrange its secondary structure into an "activated" conformation prior to cleavage. These findings lend support to the idea that RNA secondary structure is more fluid than once believed and that a better understanding of structure and dynamic features of ribozymes is required to unravel the intricacies of their catalytic abilities.
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The line below this paragraph, {{ABSTRACT_PUBMED_15328609}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15328609 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15328609}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TJZ OCA].
==Reference==
==Reference==
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[[Category: Rna hairpin]]
[[Category: Rna hairpin]]
[[Category: Rna stem-loop]]
[[Category: Rna stem-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:02:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:53:45 2008''

Revision as of 06:53, 29 July 2008

Image:1tjz.png

Template:STRUCTURE 1tjz

Solution Structure of the Active Site Stem-Loop of the VS Ribozyme

Template:ABSTRACT PUBMED 15328609

About this Structure

Full experimental information is available from OCA.

Reference

The solution structure of the VS ribozyme active site loop reveals a dynamic "hot-spot"., Flinders J, Dieckmann T, J Mol Biol. 2004 Aug 20;341(4):935-49. PMID:15328609

Page seeded by OCA on Tue Jul 29 09:53:45 2008

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