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2fx0

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[[Image:2fx0.gif|left|200px]]
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{{STRUCTURE_2fx0| PDB=2fx0 | SCENE= }}
{{STRUCTURE_2fx0| PDB=2fx0 | SCENE= }}
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'''Crystal Structure of HlyIIR, a Hemolysin II transcriptional Regulator'''
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===Crystal Structure of HlyIIR, a Hemolysin II transcriptional Regulator===
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==Overview==
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Production of Bacillus cereus and Bacillus anthracis toxins is controlled by a number of transcriptional regulators. Here we report the crystal structure of B. cereus HlyIIR, a regulator of the gene encoding the pore-forming toxin hemolysin II. We show that HlyIIR forms a tight dimer with a fold and overall architecture similar to the TetR family of repressors. A remarkable feature of the structure is a large internal cavity with a volume of 550 A(3) suggesting that the activity of HlyIIR is modulated by binding of a ligand, which triggers the toxin production. Virtual ligand library screening shows that this pocket can accommodate compounds with molecular masses of up to 400-500 Da. Based on structural data and previous biochemical evidence, we propose a model for HlyIIR interaction with the DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 17097673 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17097673}}
==About this Structure==
==About this Structure==
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[[Category: Solonin, A S.]]
[[Category: Solonin, A S.]]
[[Category: Transcriptional regulator]]
[[Category: Transcriptional regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:24:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:57:37 2008''

Revision as of 06:57, 29 July 2008

Image:2fx0.png

Template:STRUCTURE 2fx0

Crystal Structure of HlyIIR, a Hemolysin II transcriptional Regulator

Template:ABSTRACT PUBMED 17097673

About this Structure

2FX0 is a Single protein structure of sequence from Bacillus cereus. Full crystallographic information is available from OCA.

Reference

Crystal structure of Bacillus cereus HlyIIR, a transcriptional regulator of the gene for pore-forming toxin hemolysin II., Kovalevskiy OV, Lebedev AA, Surin AK, Solonin AS, Antson AA, J Mol Biol. 2007 Jan 19;365(3):825-34. Epub 2006 Oct 26. PMID:17097673

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