2gdy

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[[Image:2gdy.gif|left|200px]]
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{{STRUCTURE_2gdy| PDB=2gdy | SCENE= }}
{{STRUCTURE_2gdy| PDB=2gdy | SCENE= }}
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'''Solution structure of the B. brevis TycC3-PCP in A-state'''
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===Solution structure of the B. brevis TycC3-PCP in A-state===
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==Overview==
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Protein dynamics plays an important role in protein function. Many functionally important motions occur on the microsecond and low millisecond time scale and can be characterized by nuclear magnetic resonance relaxation experiments. We describe the different states of a peptidyl carrier protein (PCP) that play a crucial role in its function as a peptide shuttle in the nonribosomal peptide synthetases of the tyrocidine A system. Both apo-PCP (without the bound 4'-phosphopantetheine cofactor) and holo-PCP exist in two different stable conformations. We show that one of the apo conformations and one of the holo conformations are identical, whereas the two remaining conformations are only detectable by nuclear magnetic resonance spectroscopy in either the apo or holo form. We further demonstrate that this conformational diversity is an essential prerequisite for the directed movement of the 4'-PP cofactor and its interaction with externally acting proteins such as thioesterases and 4'-PP transferase.
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The line below this paragraph, {{ABSTRACT_PUBMED_16614225}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16614225 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16614225}}
==About this Structure==
==About this Structure==
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2GDY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDY OCA].
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2GDY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brevibacillus_parabrevis Brevibacillus parabrevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GDY OCA].
==Reference==
==Reference==
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[[Category: Rogov, V V.]]
[[Category: Rogov, V V.]]
[[Category: Three-helix bundle]]
[[Category: Three-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:59:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:02:36 2008''

Revision as of 07:02, 29 July 2008

Image:2gdy.png

Template:STRUCTURE 2gdy

Solution structure of the B. brevis TycC3-PCP in A-state

Template:ABSTRACT PUBMED 16614225

About this Structure

2GDY is a Single protein structure of sequence from Brevibacillus parabrevis. Full experimental information is available from OCA.

Reference

Conformational switches modulate protein interactions in peptide antibiotic synthetases., Koglin A, Mofid MR, Lohr F, Schafer B, Rogov VV, Blum MM, Mittag T, Marahiel MA, Bernhard F, Dotsch V, Science. 2006 Apr 14;312(5771):273-6. PMID:16614225

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