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1xs5

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{{STRUCTURE_1xs5| PDB=1xs5 | SCENE= }}
{{STRUCTURE_1xs5| PDB=1xs5 | SCENE= }}
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'''The Crystal Structure of Lipoprotein Tp32 from Treponema pallidum'''
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===The Crystal Structure of Lipoprotein Tp32 from Treponema pallidum===
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==Overview==
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A structure-to-function approach was undertaken to gain insights into the potential function of the 32-kDa membrane lipoprotein (Tp32) of Treponema pallidum, the syphilis bacterium. The crystal structure of rTp32 (determined at a resolution of 1.85 A) shows that the organization of rTp32 is similar to other periplasmic ligand-binding proteins (PLBPs), in that it consists of two alpha/beta domains, linked by two crossovers, with a binding pocket between them. In the pocket, a molecule of L-methionine was detected in the electron density map. Residues from both domains interact with the ligand. One of the crossover regions is comprised of a 3(10)-helix, a feature not typical in other ligand-binding proteins. Sequence comparison shows strong similarity to other hypothetical methionine-binding proteins. Together, the data support the notion that rTp32 is a component of a periplasmic methionine uptake transporter system in T. pallidum.
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(as it appears on PubMed at http://www.pubmed.gov), where 15489229 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15489229}}
==About this Structure==
==About this Structure==
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[[Category: Methionine]]
[[Category: Methionine]]
[[Category: Periplasmic binding protein]]
[[Category: Periplasmic binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:26:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:05:48 2008''

Revision as of 07:05, 29 July 2008

Image:1xs5.png

Template:STRUCTURE 1xs5

The Crystal Structure of Lipoprotein Tp32 from Treponema pallidum

Template:ABSTRACT PUBMED 15489229

About this Structure

1XS5 is a Single protein structure of sequence from Treponema pallidum. Full crystallographic information is available from OCA.

Reference

Structural evidence that the 32-kilodalton lipoprotein (Tp32) of Treponema pallidum is an L-methionine-binding protein., Deka RK, Neil L, Hagman KE, Machius M, Tomchick DR, Brautigam CA, Norgard MV, J Biol Chem. 2004 Dec 31;279(53):55644-50. Epub 2004 Oct 15. PMID:15489229

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