2ac1

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{{STRUCTURE_2ac1| PDB=2ac1 | SCENE= }}
{{STRUCTURE_2ac1| PDB=2ac1 | SCENE= }}
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'''Crystal structure of a cell-wall invertase from Arabidopsis thaliana'''
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===Crystal structure of a cell-wall invertase from Arabidopsis thaliana===
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==Overview==
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Cell-wall invertases play crucial roles during plant development. They hydrolyse sucrose into its fructose and glucose subunits by cleavage of the alpha1-beta2 glycosidic bond. Here, the structure of the Arabidopsis thaliana cell-wall invertase 1 (AtcwINV1; gene accession code At3g13790) is described at a resolution of 2.15 A. The structure comprises an N-terminal fivefold beta-propeller domain followed by a C-terminal domain formed by two beta-sheets. The active site is positioned in the fivefold beta-propeller domain, containing the nucleophile Asp23 and the acid/base catalyst Glu203 of the double-displacement enzymatic reaction. The function of the C-terminal domain remains unknown. Unlike in other GH 32 family enzyme structures known to date, in AtcwINV1 the cleft formed between both domains is blocked by Asn299-linked carbohydrates. A preliminary site-directed mutagenesis experiment (Asn299Asp) removed the glycosyl chain but did not alter the activity profile of the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 17139091 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17139091}}
==About this Structure==
==About this Structure==
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[[Category: Verhaest, M.]]
[[Category: Verhaest, M.]]
[[Category: Five fold beta propeller]]
[[Category: Five fold beta propeller]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:51:55 2008''
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Revision as of 07:06, 29 July 2008

Image:2ac1.png

Template:STRUCTURE 2ac1

Crystal structure of a cell-wall invertase from Arabidopsis thaliana

Template:ABSTRACT PUBMED 17139091

About this Structure

2AC1 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

X-ray diffraction structure of a cell-wall invertase from Arabidopsis thaliana., Verhaest M, Lammens W, Le Roy K, De Coninck B, De Ranter CJ, Van Laere A, Van den Ende W, Rabijns A, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1555-63. Epub 2006, Nov 23. PMID:17139091

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