This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i28

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2i28.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2i28.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2i28| PDB=2i28 | SCENE= }}
{{STRUCTURE_2i28| PDB=2i28 | SCENE= }}
-
'''Solution Structure of alpha-Conotoxin BuIA'''
+
===Solution Structure of alpha-Conotoxin BuIA===
-
==Overview==
+
<!--
-
We have determined a high-resolution three-dimensional structure of alpha-conotoxin BuIA, a 13-residue peptide toxin isolated from Conus bullatus. Despite its unusual 4/4 disulfide bond layout alpha-conotoxin BuIA exhibits strong antagonistic activity at alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nAChR subtypes like some alpha4/7 conotoxins. alpha-Conotoxin BuIA lacks the C-terminal beta-turn present within the second disulfide loop of alpha4/7 conotoxins, having only a "pseudo omega-shaped" molecular topology. Nevertheless, it contains a functionally critical two-turn helix motif, a feature ubiquitously found in alpha4/7 conotoxins. Such an aspect seems mainly responsible for similarities in the receptor recognition profile of alpha-conotoxin BuIA to alpha4/7 conotoxins. Structural comparison of alpha-conotoxin BuIA with alpha4/7 conotoxins and alpha4/3 conotoxin ImI suggests that presence of the second helical turn portion of the two-turn helix motif in alpha4/7 and alpha4/4 conotoxins may be important for binding to the alpha3 and/or alpha6 subunit of nAChR.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16979596}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16979596 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16979596}}
==About this Structure==
==About this Structure==
-
2I28 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA].
+
2I28 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA].
==Reference==
==Reference==
Line 30: Line 34:
[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:59:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:07:51 2008''

Revision as of 07:07, 29 July 2008

Image:2i28.png

Template:STRUCTURE 2i28

Solution Structure of alpha-Conotoxin BuIA

Template:ABSTRACT PUBMED 16979596

About this Structure

2I28 is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Nov 3;349(4):1228-34. Epub 2006 Sep 7. PMID:16979596

Page seeded by OCA on Tue Jul 29 10:07:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i28"
Personal tools