2hai

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{{STRUCTURE_2hai| PDB=2hai | SCENE= }}
{{STRUCTURE_2hai| PDB=2hai | SCENE= }}
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'''Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.'''
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===Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.===
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==Overview==
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A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure-activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.
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(as it appears on PubMed at http://www.pubmed.gov), where 16824756 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16824756}}
==About this Structure==
==About this Structure==
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[[Category: Love, R L.]]
[[Category: Love, R L.]]
[[Category: Hcv rna polymerase]]
[[Category: Hcv rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:03:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:08:06 2008''

Revision as of 07:08, 29 July 2008

Image:2hai.png

Template:STRUCTURE 2hai

Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.

Template:ABSTRACT PUBMED 16824756

About this Structure

2HAI is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors., Li H, Tatlock J, Linton A, Gonzalez J, Borchardt A, Dragovich P, Jewell T, Prins T, Zhou R, Blazel J, Parge H, Love R, Hickey M, Doan C, Shi S, Duggal R, Lewis C, Fuhrman S, Bioorg Med Chem Lett. 2006 Sep 15;16(18):4834-8. Epub 2006 Jul 7. PMID:16824756

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