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1pto

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(New page: 200px<br /><applet load="1pto" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pto, resolution 3.5Å" /> '''THE STRUCTURE OF A PE...)
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Revision as of 21:59, 20 November 2007

Image:1pto.jpg

THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING

Overview

Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis, which is important the pathogenesis of whooping cough and the generation, of a protective immune response. The diverse biological activities of the, toxin depend on its ability to recognize carbohydrate-containing receptors, on a wide variety of eukaryotic cells. We present here the crystal, structure of pertussis toxin complexed with a soluble oligosaccharide from, transferrin. Binding sites for the terminal sialic acid-galactose moiety, are revealed on both subunits S2 and S3 of the B-oligomer. Identification, of amino acid residues involved in receptor binding will improve the, design of genetically inactivated toxins for use in new acellular whooping, cough vaccines.

About this Structure

1PTO is a Protein complex structure of sequences from Bordetella pertussis. Full crystallographic information is available from OCA.

Reference

Structure of a pertussis toxin-sugar complex as a model for receptor binding., Stein PE, Boodhoo A, Armstrong GD, Heerze LD, Cockle SA, Klein MH, Read RJ, Nat Struct Biol. 1994 Sep;1(9):591-6. PMID:7634099

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