This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1ptq
From Proteopedia
OCA (Talk | contribs)
(New page: 200px<br /><applet load="1ptq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ptq, resolution 1.95Å" /> '''PROTEIN KINASE C DEL...)
Next diff →
Revision as of 21:59, 20 November 2007
|
PROTEIN KINASE C DELTA CYS2 DOMAIN
Overview
Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes, that associate with membranes and are activated by diacylglycerol or, tumor-promoting agonists such as phorbol esters. The structure of the, second activator-binding domain of PKC delta has been determined in, complex with phorbol 13-acetate, which binds in a groove between two, pulled-apart beta strands at the tip of the domain. The C3, C4, and C20, phorbol oxygens form hydrogen bonds with main-chain groups whose, orientation is controlled by a set of highly conserved residues. Phorbol, binding caps the groove and forms a contiguous hydrophobic surface, covering one-third of the domain, explaining how the activator promotes, insertion of PKC into membranes.
About this Structure
1PTQ is a Single protein structure of sequence from Mus musculus with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:7781068
Page seeded by OCA on Wed Nov 21 00:07:11 2007
