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1p7q

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{{STRUCTURE_1p7q| PDB=1p7q | SCENE= }}
{{STRUCTURE_1p7q| PDB=1p7q | SCENE= }}
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'''Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor'''
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===Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor===
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==Overview==
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Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.
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(as it appears on PubMed at http://www.pubmed.gov), where 12897781 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12897781}}
==Disease==
==Disease==
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[[Category: Willcox, B E.]]
[[Category: Willcox, B E.]]
[[Category: Hla-a2/lir-1 complex]]
[[Category: Hla-a2/lir-1 complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:47:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:14:09 2008''

Revision as of 07:14, 29 July 2008

Image:1p7q.png

Template:STRUCTURE 1p7q

Contents

Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC Receptor

Template:ABSTRACT PUBMED 12897781

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1P7Q is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor., Willcox BE, Thomas LM, Bjorkman PJ, Nat Immunol. 2003 Sep;4(9):913-9. Epub 2003 Aug 3. PMID:12897781

Page seeded by OCA on Tue Jul 29 10:14:09 2008

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