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1qwj

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[[Image:1qwj.gif|left|200px]]
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{{Seed}}
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[[Image:1qwj.png|left|200px]]
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{{STRUCTURE_1qwj| PDB=1qwj | SCENE= }}
{{STRUCTURE_1qwj| PDB=1qwj | SCENE= }}
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'''The Crystal Structure of Murine CMP-5-N-Acetylneuraminic Acid Synthetase'''
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===The Crystal Structure of Murine CMP-5-N-Acetylneuraminic Acid Synthetase===
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==Overview==
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Sialic acids are activated by CMP-5-N-acetylneuraminic acid synthetase prior to their transfer onto oligo- or polysaccharides. Here, we present the crystal structure of the N-terminal catalytically active domain of the murine 5-N-acetylneuraminic acid synthetase in complex with the reaction product. In contrast to the previously solved structure of 5-N-acetylneuraminic acid synthetase from Neisseria meningitidis and the related CMP-KDO-synthetase of Escherichia coli, the murine enzyme is a tetramer, which was observed with the active sites closed. In this conformation a loop is shifted by 6A towards the active site and thus an essential arginine residue can participate in catalysis. Furthermore, a network of intermolecular salt-bridges and hydrogen bonds in the dimer as well as hydrophobic interfaces between two dimers indicate a cooperative behaviour of the enzyme. In addition, a complex regulation of the enzyme activity is proposed that includes phosphorylation and dephosphorylation.
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The line below this paragraph, {{ABSTRACT_PUBMED_14636592}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14636592 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14636592}}
==About this Structure==
==About this Structure==
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[[Category: Sialic acid]]
[[Category: Sialic acid]]
[[Category: Sugar-activating enzyme]]
[[Category: Sugar-activating enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:46:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:26:31 2008''

Revision as of 07:26, 29 July 2008

Image:1qwj.png

Template:STRUCTURE 1qwj

The Crystal Structure of Murine CMP-5-N-Acetylneuraminic Acid Synthetase

Template:ABSTRACT PUBMED 14636592

About this Structure

1QWJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of murine CMP-5-N-acetylneuraminic acid synthetase., Krapp S, Munster-Kuhnel AK, Kaiser JT, Huber R, Tiralongo J, Gerardy-Schahn R, Jacob U, J Mol Biol. 2003 Dec 5;334(4):625-37. PMID:14636592

Page seeded by OCA on Tue Jul 29 10:26:31 2008

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