2eb7

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{{STRUCTURE_2eb7| PDB=2eb7 | SCENE= }}
{{STRUCTURE_2eb7| PDB=2eb7 | SCENE= }}
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'''Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7'''
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===Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7===
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==Overview==
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The emergence of bacterial resistance to multiple drugs poses a serious and growing health concern. Understanding and deciphering the mechanisms of these multiple drug resistance regulatory proteins through structural or biochemical means is an important endeavor. Here, we present the crystal structure of ST1710 from Sulfolobus tokodaii strain 7 in two different crystal forms, at 1.80 and 2.0A, respectively. The overall structure of the ST1710 dimer shares the topology of the MarR family of proteins, with each subunit containing a winged helix-turn-helix DNA-binding motif. We also show the protein-DNA interactions by biochemical methods. Our molecular modeling analysis suggested that Asp88 and Arg90 are the key residues in ST1710 involved in the protein-DNA interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17933554 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17933554}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Transcription regulator]]
[[Category: Transcription regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 02:16:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:30:16 2008''

Revision as of 07:30, 29 July 2008

Image:2eb7.png

Template:STRUCTURE 2eb7

Crystal structure of the hypothetical regulator from Sulfolobus tokodaii 7

Template:ABSTRACT PUBMED 17933554

About this Structure

2EB7 is a Single protein structure of sequence from Sulfolobus tokodaii. Full crystallographic information is available from OCA.

Reference

Crystal structure of the MarR family regulatory protein, ST1710, from Sulfolobus tokodaii strain 7., Kumarevel T, Tanaka T, Nishio M, Gopinath SC, Takio K, Shinkai A, Kumar PK, Yokoyama S, J Struct Biol. 2008 Jan;161(1):9-17. Epub 2007 Sep 8. PMID:17933554

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