1mx0

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[[Image:1mx0.gif|left|200px]]
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{{Seed}}
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[[Image:1mx0.png|left|200px]]
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{{STRUCTURE_1mx0| PDB=1mx0 | SCENE= }}
{{STRUCTURE_1mx0| PDB=1mx0 | SCENE= }}
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'''Structure of topoisomerase subunit'''
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===Structure of topoisomerase subunit===
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==Overview==
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Type IIA and type IIB topoisomerases each possess the ability to pass one DNA duplex through another in an ATP-dependent manner. The role of ATP in the strand passage reaction is poorly understood, particularly for the type IIB (topoisomerase VI) family. We have solved the structure of the ATP-binding subunit of topoisomerase VI (topoVI-B) in two states: an unliganded monomer and a nucleotide-bound dimer. We find that topoVI-B is highly structurally homologous to the entire 40-43 kDa ATPase region of type IIA topoisomerases and MutL proteins. Nucleotide binding to topoVI-B leads to dimerization of the protein and causes dramatic conformational changes within each protomer. Our data demonstrate that type IIA and type IIB topoisomerases have descended from a common ancestor and reveal how ATP turnover generates structural signals in the reactions of both type II topoisomerase families. When combined with the structure of the A subunit to create a picture of the intact topoisomerase VI holoenzyme, the ATP-driven motions of topoVI-B reveal a simple mechanism for strand passage by the type IIB topoisomerases.
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The line below this paragraph, {{ABSTRACT_PUBMED_12505993}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12505993 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12505993}}
==About this Structure==
==About this Structure==
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[[Category: Ghkl atpase]]
[[Category: Ghkl atpase]]
[[Category: Topoisomerase]]
[[Category: Topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:49:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:37:18 2008''

Revision as of 07:37, 29 July 2008

Image:1mx0.png

Template:STRUCTURE 1mx0

Structure of topoisomerase subunit

Template:ABSTRACT PUBMED 12505993

About this Structure

1MX0 is a Single protein structure of sequence from Sulfolobus shibatae. Full crystallographic information is available from OCA.

Reference

Structure of the topoisomerase VI-B subunit: implications for type II topoisomerase mechanism and evolution., Corbett KD, Berger JM, EMBO J. 2003 Jan 2;22(1):151-63. PMID:12505993

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