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2orl

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[[Image:2orl.gif|left|200px]]
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{{STRUCTURE_2orl| PDB=2orl | SCENE= }}
{{STRUCTURE_2orl| PDB=2orl | SCENE= }}
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'''Solution structure of the cytochrome c- para-aminophenol adduct'''
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===Solution structure of the cytochrome c- para-aminophenol adduct===
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==Overview==
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Protein-protein interactions are driven by specific properties of the molecular surfaces. Cytochrome c, a small electron transfer protein, is involved in a number of biologically relevant interactions with macromolecular partners. Small molecules may interfere with such interactions by binding to the surface of cytochrome c. Here we investigated the possibility of weak intermolecular interactions between reduced cytochrome c and a library of 325 small molecules, using WaterLOGSY NMR spectroscopy. Specific binding was found for p-aminophenol. The solution structure of the p-aminophenol-cytochrome c adduct was determined using a combination of in silico tools and NMR-based restraints. The ligand interacts in a specific binding site on the protein surface through a combination of stacking and H-bond interactions. Small but meaningful rearrangements of the solvent-exposed side chains are observed upon ligand binding and contribute to the stabilization of the complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 17488096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17488096}}
==About this Structure==
==About this Structure==
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2ORL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].
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2ORL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORL OCA].
==Reference==
==Reference==
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[[Category: Turano, P.]]
[[Category: Turano, P.]]
[[Category: Protein-ligand adduct]]
[[Category: Protein-ligand adduct]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:31:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:40:58 2008''

Revision as of 07:41, 29 July 2008

Image:2orl.png

Template:STRUCTURE 2orl

Solution structure of the cytochrome c- para-aminophenol adduct

Template:ABSTRACT PUBMED 17488096

About this Structure

2ORL is a Single protein structure of sequence from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

Cytochrome c and organic molecules: solution structure of the p-aminophenol adduct., Assfalg M, Bertini I, Del Conte R, Giachetti A, Turano P, Biochemistry. 2007 May 29;46(21):6232-8. Epub 2007 May 9. PMID:17488096

Page seeded by OCA on Tue Jul 29 10:40:58 2008

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