2h03

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[[Image:2h03.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2h03| PDB=2h03 | SCENE= }}
{{STRUCTURE_2h03| PDB=2h03 | SCENE= }}
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'''Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors'''
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===Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors===
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==Overview==
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The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPbeta. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPbeta potency.
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The line below this paragraph, {{ABSTRACT_PUBMED_16759857}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16759857 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16759857}}
==About this Structure==
==About this Structure==
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[[Category: Sulfamic acid]]
[[Category: Sulfamic acid]]
[[Category: Wpd-loop]]
[[Category: Wpd-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:42:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:41:10 2008''

Revision as of 07:41, 29 July 2008

Image:2h03.png

Template:STRUCTURE 2h03

Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

Template:ABSTRACT PUBMED 16759857

About this Structure

2H03 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta., Amarasinghe KK, Evidokimov AG, Xu K, Clark CM, Maier MB, Srivastava A, Colson AO, Gerwe GS, Stake GE, Howard BW, Pokross ME, Gray JL, Peters KG, Bioorg Med Chem Lett. 2006 Aug 15;16(16):4252-6. Epub 2006 Jun 12. PMID:16759857

Page seeded by OCA on Tue Jul 29 10:41:10 2008

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