2rdd

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[[Image:2rdd.jpg|left|200px]]
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{{STRUCTURE_2rdd| PDB=2rdd | SCENE= }}
{{STRUCTURE_2rdd| PDB=2rdd | SCENE= }}
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'''X-ray crystal structure of AcrB in complex with a novel transmembrane helix.'''
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===X-ray crystal structure of AcrB in complex with a novel transmembrane helix.===
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==Overview==
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Bacterial drug resistance is a serious concern for human health. Multidrug efflux pumps export a broad variety of substrates out of the cell and thereby convey resistance to the host. In Escherichia coli, the AcrB:AcrA:TolC efflux complex forms a principal transporter for which structures of the individual component proteins have been determined in isolation. Here, we present the X-ray structure of AcrB in complex with a single transmembrane protein, assigned by mass spectrometry as YajC. A specific rotation of the periplasmic porter domain of AcrB is also revealed, consistent with the hypothesized "twist-to-open" mechanism for TolC activation. Growth experiments with yajc-deleted E. coli reveal a modest increase in the organism's susceptibility to beta-lactam antibiotics, but this effect could not conclusively be attributed to the loss of interactions between YajC and AcrB.
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(as it appears on PubMed at http://www.pubmed.gov), where 18073115 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18073115}}
==About this Structure==
==About this Structure==
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[[Category: Transporter]]
[[Category: Transporter]]
[[Category: Yajc]]
[[Category: Yajc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:07:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:47:41 2008''

Revision as of 07:47, 29 July 2008

Image:2rdd.png

Template:STRUCTURE 2rdd

X-ray crystal structure of AcrB in complex with a novel transmembrane helix.

Template:ABSTRACT PUBMED 18073115

About this Structure

2RDD is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist., Tornroth-Horsefield S, Gourdon P, Horsefield R, Brive L, Yamamoto N, Mori H, Snijder A, Neutze R, Structure. 2007 Dec;15(12):1663-73. PMID:18073115

Page seeded by OCA on Tue Jul 29 10:47:41 2008

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