2iro

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[[Image:2iro.jpg|left|200px]]
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{{Seed}}
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[[Image:2iro.png|left|200px]]
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{{STRUCTURE_2iro| PDB=2iro | SCENE= }}
{{STRUCTURE_2iro| PDB=2iro | SCENE= }}
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'''The NMR Structures of (rGCUGAGGCU)2 and (rGCGGAUGCU)2'''
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===The NMR Structures of (rGCUGAGGCU)2 and (rGCGGAUGCU)2===
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==Overview==
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The NMR structures of [see text] and [see text] are reported. The internal loop, [see text], is about 2 kcal/mol more stable than [see text] at 37 degrees C. The duplexes assemble into similar global folds characterized by the formation of tandem sheared GA pairs. The different stabilities of the loops are accompanied by differences in the local structure of the closing GU pairs. In the [see text] internal loop, the GU pairs form canonical wobble configurations with two hydrogen bonds, whereas in [see text], the GU pairs form a single hydrogen bond involving the amino group, GH22, and the carbonyl group, UO4. This pairing is similar to the GU closing pair of the 690 hairpin loop found in E. coli 16S rRNA. The [see text] and [see text] structures reveal how the subtle interplay between stacking and hydrogen bonding determines sequence dependent conformation and thermodynamic stability. Thus, this work provides structural and thermodynamic benchmarks for theoreticians in the ongoing effort to understand the sequence dependence of RNA physicochemical properties.
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The line below this paragraph, {{ABSTRACT_PUBMED_17279616}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17279616 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17279616}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRO OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IRO OCA].
==Reference==
==Reference==
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[[Category: Sheared gu pair]]
[[Category: Sheared gu pair]]
[[Category: Thermodynamic]]
[[Category: Thermodynamic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:47:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:01:58 2008''

Revision as of 08:02, 29 July 2008

Image:2iro.png

Template:STRUCTURE 2iro

The NMR Structures of (rGCUGAGGCU)2 and (rGCGGAUGCU)2

Template:ABSTRACT PUBMED 17279616

About this Structure

Full experimental information is available from OCA.

Reference

NMR structures of (rGCUGAGGCU)2 and (rGCGGAUGCU)2: probing the structural features that shape the thermodynamic stability of GA pairs., Tolbert BS, Kennedy SD, Schroeder SJ, Krugh TR, Turner DH, Biochemistry. 2007 Feb 13;46(6):1511-22. Epub 2007 Jan 20. PMID:17279616

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