2qtj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
 +
{{Seed}}
 +
[[Image:2qtj.png|left|200px]]
 +
<!--
<!--
The line below this paragraph, containing "STRUCTURE_2qtj", creates the "Structure Box" on the page.
The line below this paragraph, containing "STRUCTURE_2qtj", creates the "Structure Box" on the page.
Line 7: Line 10:
{{STRUCTURE_2qtj| PDB=2qtj | SCENE= }}
{{STRUCTURE_2qtj| PDB=2qtj | SCENE= }}
-
'''Solution structure of human dimeric immunoglobulin A'''
+
===Solution structure of human dimeric immunoglobulin A===
-
==Overview==
+
<!--
-
IgA is unique in being able to form a diverse range of polymeric structures. Increases in the levels of dimeric IgA1 (dIgA1) in serum have been implicated in diseases such as IgA nephropathy. We have determined the solution structure for dIgA1 by synchrotron x-ray and neutron scattering and analytical ultracentrifugation. The Guinier radius of gyration (RG) of 7.60-8.65 nm indicated that the two monomers within dIgA1 are arranged in an extended conformation. The distance distribution curve P(r) gave an overall length (L) of 22-26 nm. These results were confirmed by the sedimentation coefficient and frictional ratio of dIgA1. Constrained scattering modeling starting from the IgA1 monomer solution structure revealed a near-planar dimer structure for dIgA1. The two Fc regions form a slightly bent arrangement in which they form end-to-end contacts, and the J chain was located at this interface. This structure was refined by optimizing the position of the four Fab regions. From this, the best-fit solution structures show that the four Fab Ag-binding sites are independent of one another, and the two Fc regions are accessible to receptor binding. This arrangement allows dIgA1 to initiate specific immune responses by binding to FcalphaRI receptors, while still retaining Ag-binding ability, and to be selectively transported to mucosal surfaces by binding to the polymeric Ig receptor to form secretory IgA. A mechanism for the involvement of dIgA1 oligomers in the pathology of IgA nephropathy is discussed in the light of this near-planar structure.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18178841}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18178841 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18178841}}
==About this Structure==
==About this Structure==
Line 36: Line 42:
[[Category: Polymorphism]]
[[Category: Polymorphism]]
[[Category: X-ray and neutron solution scattering]]
[[Category: X-ray and neutron solution scattering]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:39:15 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:02:20 2008''

Revision as of 08:02, 29 July 2008

Image:2qtj.png

Template:STRUCTURE 2qtj

Solution structure of human dimeric immunoglobulin A

Template:ABSTRACT PUBMED 18178841

About this Structure

2QTJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy., Bonner A, Furtado PB, Almogren A, Kerr MA, Perkins SJ, J Immunol. 2008 Jan 15;180(2):1008-18. PMID:18178841

Page seeded by OCA on Tue Jul 29 11:02:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qtj"
Personal tools