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2afe

From Proteopedia

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[[Image:2afe.gif|left|200px]]
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{{STRUCTURE_2afe| PDB=2afe | SCENE= }}
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'''Solution Structure of Asl1650, an Acyl Carrier Protein from Anabaena sp. PCC 7120 with a Variant Phosphopantetheinylation-Site Sequence'''
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===Solution Structure of Asl1650, an Acyl Carrier Protein from Anabaena sp. PCC 7120 with a Variant Phosphopantetheinylation-Site Sequence===
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==Overview==
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Cyanobacteria, such as Anabaena, produce a variety of bioactive natural products via polyketide synthases (PKS), nonribosomal peptide synthetases (NRPS), and hybrid peptide/polyketide pathways. The protein Asl1650, which is a member of the acyl carrier protein family from the cyanobacterium Anabaena sp. PCC 7120, is encoded in a region of the Anabaena genome that is rich in PKS and NRPS genes. To gain new insight into the physiological role of acyl carriers in Anabaena, the solution structure of Asl1650 has been solved by NMR spectroscopy. The protein adopts a twisted antiparallel four-helix bundle fold, with a variant phosphopantetheine-attachment motif positioned at the start of the second helix. Structure comparisons with proteins from other organisms suggest a likely physiological function as a discrete peptidyl carrier protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 16597827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16597827}}
==About this Structure==
==About this Structure==
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2AFE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFE OCA].
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2AFE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anabaena_sp. Anabaena sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFE OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Twisted antiparallel helical bundle]]
[[Category: Twisted antiparallel helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:58:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:07:14 2008''

Revision as of 08:07, 29 July 2008

Image:2afe.png

Template:STRUCTURE 2afe

Solution Structure of Asl1650, an Acyl Carrier Protein from Anabaena sp. PCC 7120 with a Variant Phosphopantetheinylation-Site Sequence

Template:ABSTRACT PUBMED 16597827

About this Structure

2AFE is a Single protein structure of sequence from Anabaena sp.. Full experimental information is available from OCA.

Reference

Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence., Johnson MA, Peti W, Herrmann T, Wilson IA, Wuthrich K, Protein Sci. 2006 May;15(5):1030-41. Epub 2006 Apr 5. PMID:16597827

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