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2hde

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{{STRUCTURE_2hde| PDB=2hde | SCENE= }}
{{STRUCTURE_2hde| PDB=2hde | SCENE= }}
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'''Solution Structure of Human SAP18'''
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===Solution Structure of Human SAP18===
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==Overview==
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Signal transduction pathways are frequently found to repress transcription of target genes in the absence of stimulation and, conversely, to upregulate transcription in the presence of a signal. Transcription factors are central in this dual regulatory mechanism and widely use a generalized mechanism to repress transcription through recruitment of a Sin3-histone deacetylase (HDAC) complex to their binding sites on DNA. The protein SAP18 (Sin3-associated polypeptide of 18 kDa) has been shown to play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. The solution structure of SAP18 reveals a ubiquitin-like fold with several large loop insertions relative to other family members. This fold supports the functional role of SAP18 as a protein-protein adapter module and provides insight for how SAP18 may bridge the Sin3-HDAC complex to transcription factors.
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{{ABSTRACT_PUBMED_17002296}}
==About this Structure==
==About this Structure==
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2HDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDE OCA].
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2HDE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HDE OCA].
==Reference==
==Reference==
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[[Category: Sin3]]
[[Category: Sin3]]
[[Category: Transcriptional repressor]]
[[Category: Transcriptional repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:08:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:12:24 2008''

Revision as of 08:12, 29 July 2008

Image:2hde.png

Template:STRUCTURE 2hde

Solution Structure of Human SAP18

Template:ABSTRACT PUBMED 17002296

About this Structure

2HDE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly., McCallum SA, Bazan JF, Merchant M, Yin J, Pan B, de Sauvage FJ, Fairbrother WJ, Biochemistry. 2006 Oct 3;45(39):11974-82. PMID:17002296

Page seeded by OCA on Tue Jul 29 11:12:24 2008

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