1t6g

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{{STRUCTURE_1t6g| PDB=1t6g | SCENE= }}
{{STRUCTURE_1t6g| PDB=1t6g | SCENE= }}
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'''Crystal structure of the Triticum aestivum xylanase inhibitor-I in complex with aspergillus niger xylanase-I'''
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===Crystal structure of the Triticum aestivum xylanase inhibitor-I in complex with aspergillus niger xylanase-I===
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==Overview==
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Plants developed a diverse battery of defense mechanisms in response to continual challenges by a broad spectrum of pathogenic microorganisms. Their defense arsenal includes inhibitors of cell wall-degrading enzymes, which hinder a possible invasion and colonization by antagonists. The structure of Triticum aestivum xylanase inhibitor-I (TAXI-I), a first member of potent TAXI-type inhibitors of fungal and bacterial family 11 xylanases, has been determined to 1.7-A resolution. Surprisingly, TAXI-I displays structural homology with the pepsin-like family of aspartic proteases but is proteolytically nonfunctional, because one or more residues of the essential catalytical triad are absent. The structure of the TAXI-I.Aspergillus niger xylanase I complex, at a resolution of 1.8 A, illustrates the ability of tight binding and inhibition with subnanomolar affinity and indicates the importance of the C-terminal end for the differences in xylanase specificity among different TAXI-type inhibitors.
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{{ABSTRACT_PUBMED_15166216}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Two beta-barrel domain structure]]
[[Category: Two beta-barrel domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:15:14 2008''

Revision as of 08:15, 29 July 2008

Image:1t6g.png

Template:STRUCTURE 1t6g

Crystal structure of the Triticum aestivum xylanase inhibitor-I in complex with aspergillus niger xylanase-I

Template:ABSTRACT PUBMED 15166216

About this Structure

1T6G is a Protein complex structure of sequences from Aspergillus niger and Triticum aestivum. Full crystallographic information is available from OCA.

Reference

Structural basis for inhibition of Aspergillus niger xylanase by triticum aestivum xylanase inhibitor-I., Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA, Rabijns A, J Biol Chem. 2004 Aug 20;279(34):36022-8. Epub 2004 May 27. PMID:15166216

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