1wck

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{{STRUCTURE_1wck| PDB=1wck | SCENE= }}
{{STRUCTURE_1wck| PDB=1wck | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.'''
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===CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.===
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==Overview==
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The lethal disease anthrax is propagated by spores of Bacillus anthracis, which can penetrate into the mammalian host by inhalation, causing a rapid progression of the disease and a mostly fatal outcome. We have solved the three-dimensional structure of the major surface protein BclA on B. anthracis spores. Surprisingly, the structure resembles C1q, the first component of complement, despite there being no sequence homology. Although most assays for C1q-like activity, including binding to C1q receptors, suggest that BclA does not mimic C1q, we show that BclA, as well as C1q, interacts with components of the lung alveolar surfactant layer. Thus, to better recognize and invade its hosts, this pathogenic soil bacterium may have evolved a surface protein whose structure is strikingly close to a mammalian protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 16249180 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16249180}}
==About this Structure==
==About this Structure==
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[[Category: Collagen-like protein]]
[[Category: Collagen-like protein]]
[[Category: Jelly-roll topology,structural protein]]
[[Category: Jelly-roll topology,structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:28:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:18:15 2008''

Revision as of 08:18, 29 July 2008

Image:1wck.png

Template:STRUCTURE 1wck

CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF BCLA, THE MAJOR ANTIGEN OF THE EXOSPORIUM OF THE BACILLUS ANTHRACIS SPORE.

Template:ABSTRACT PUBMED 16249180

About this Structure

1WCK is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

The crystal structure of the Bacillus anthracis spore surface protein BclA shows remarkable similarity to mammalian proteins., Rety S, Salamitou S, Garcia-Verdugo I, Hulmes DJ, Le Hegarat F, Chaby R, Lewit-Bentley A, J Biol Chem. 2005 Dec 30;280(52):43073-8. Epub 2005 Oct 25. PMID:16249180

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