2bvu

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[[Image:2bvu.jpg|left|200px]]
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{{Seed}}
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[[Image:2bvu.png|left|200px]]
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{{STRUCTURE_2bvu| PDB=2bvu | SCENE= }}
{{STRUCTURE_2bvu| PDB=2bvu | SCENE= }}
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'''D83R MUTANT OF ASARIS SUUM MAJOR SPERM PROTEIN (MSP)'''
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===D83R MUTANT OF ASARIS SUUM MAJOR SPERM PROTEIN (MSP)===
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==Overview==
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Although several models have been proposed to account for how cytoskeleton polymerization drives protrusion in cell motility, the precise mechanism remains controversial. Here, we show that, in addition to force exerted directly against the membrane by growing filaments, the way elongating filaments pack also contributes to protrusion by generating an expansion of the cytoskeleton gel. Tomography shows that filament packing in the major sperm protein (MSP) -based nematode sperm-motility machinery resembles that observed with rigid rods. Maximum rod-packing density decreases dramatically as the rods lengthen. Therefore, as filaments elongate, the cytoskeleton gel expands to accommodate their packing less densely. This volume expansion combines with polymerization to drive protrusion. Consistent with this hypothesis, an engineered MSP mutant that generates shorter filaments shows higher filament-packing density and slower movement.
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(as it appears on PubMed at http://www.pubmed.gov), where 18385381 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18385381}}
==About this Structure==
==About this Structure==
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[[Category: Major sperm protein]]
[[Category: Major sperm protein]]
[[Category: Structural protein]]
[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 16 23:06:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:18:34 2008''

Revision as of 08:18, 29 July 2008

Image:2bvu.png

Template:STRUCTURE 2bvu

D83R MUTANT OF ASARIS SUUM MAJOR SPERM PROTEIN (MSP)

Template:ABSTRACT PUBMED 18385381

About this Structure

2BVU is a Single protein structure of sequence from Ascaris suum. Full crystallographic information is available from OCA.

Reference

The role of filament-packing dynamics in powering amoeboid cell motility., Miao L, Vanderlinde O, Liu J, Grant RP, Wouterse A, Shimabukuro K, Philipse A, Stewart M, Roberts TM, Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5390-5. Epub 2008 Apr 2. PMID:18385381

Page seeded by OCA on Tue Jul 29 11:18:34 2008

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