2bn2

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{{STRUCTURE_2bn2| PDB=2bn2 | SCENE= }}
{{STRUCTURE_2bn2| PDB=2bn2 | SCENE= }}
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'''CRYSTAL STRUCTURE OF BOVINE NEUROPHYSIN II COMPLEXED WITH THE VASOPRESSIN ANALOGUE PHE-TYR AMIDE'''
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===CRYSTAL STRUCTURE OF BOVINE NEUROPHYSIN II COMPLEXED WITH THE VASOPRESSIN ANALOGUE PHE-TYR AMIDE===
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==Overview==
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The crystal structure of a dipeptide complex of bovine neurophysin II has been solved at 2.8 A resolution solely by using single-wavelength anomalous scattering data from a single iodinated derivative. The asymmetric unit is an elongated tetramer of dimensions 110 x 40 x 30 A, composed of two dimers related by pseudo twofold symmetry. Each monomer consists of two homologous layers, each with four antiparallel beta-strands. The two regions are connected by a helix followed by a long loop. Monomer-monomer contacts involve antiparallel beta-sheet interactions, which form a dimer with two layers of eight beta-strands. One peptide per monomer occupies the principal hormone-binding pocket formed by part of the amino-terminal region and parts of the connecting helix and loop, with binding to protein consistent with conclusions drawn from solution studies. Dimer-dimer contacts involve the Tyr49 region adjacent to this site. A fifth dipeptide, of unknown biological significance, helps to stabilize one of the monomer-monomer interfaces and the tetramer-tetramer network in the crystal.
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(as it appears on PubMed at http://www.pubmed.gov), where 2034668 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2034668}}
==About this Structure==
==About this Structure==
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[[Category: Hormone packaging]]
[[Category: Hormone packaging]]
[[Category: Transport]]
[[Category: Transport]]
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Revision as of 08:21, 29 July 2008

Image:2bn2.png

Template:STRUCTURE 2bn2

CRYSTAL STRUCTURE OF BOVINE NEUROPHYSIN II COMPLEXED WITH THE VASOPRESSIN ANALOGUE PHE-TYR AMIDE

Template:ABSTRACT PUBMED 2034668

About this Structure

2BN2 is a Single protein structure of sequence from Bos taurus. This structure supersedes the now removed PDB entry 1bn2. Full crystallographic information is available from OCA.

Reference

Crystal structure of a bovine neurophysin II dipeptide complex at 2.8 A determined from the single-wavelength anomalous scattering signal of an incorporated iodine atom., Chen LQ, Rose JP, Breslow E, Yang D, Chang WR, Furey WF Jr, Sax M, Wang BC, Proc Natl Acad Sci U S A. 1991 May 15;88(10):4240-4. PMID:2034668

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