1nco

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[[Image:1nco.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1nco| PDB=1nco | SCENE= }}
{{STRUCTURE_1nco| PDB=1nco | SCENE= }}
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'''STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN'''
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===STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN===
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==Overview==
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Structures of the protein-chromophore complex and the apoprotein form of neocarzinostatin were determined at 1.8 angstrom resolution. Neocarzinostatin is composed of a labile chromophore with DNA-cleaving activity and a stabilizing protein. The chromophore displays marked nonlinearity of the triple bonds and is bound noncovalently in a pocket formed by the two protein domains. The chromophore pi-face interacts with the phenyl ring edges of Phe52 and Phe78. The amino sugar and carbonate groups of the chromophore are solvent exposed, whereas the epoxide, acetylene groups, and carbon C-12, the site of nucleophilic thiol addition during chromophore activation, are unexposed. The position of the amino group of the chromophore carbohydrate relative to C-12 supports the idea that the amino group plays a role in thiol activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 8235619 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8235619}}
==About this Structure==
==About this Structure==
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[[Category: Rees, D C.]]
[[Category: Rees, D C.]]
[[Category: Antibacterial and antitumor protein]]
[[Category: Antibacterial and antitumor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:22:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:23:11 2008''

Revision as of 08:23, 29 July 2008

Image:1nco.png

Template:STRUCTURE 1nco

STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN

Template:ABSTRACT PUBMED 8235619

About this Structure

1NCO is a Single protein structure of sequence from Streptomyces carzinostaticus. Full crystallographic information is available from OCA.

Reference

Crystal structure of neocarzinostatin, an antitumor protein-chromophore complex., Kim KH, Kwon BM, Myers AG, Rees DC, Science. 1993 Nov 12;262(5136):1042-6. PMID:8235619

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