1q12

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1q12.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1q12.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1q12| PDB=1q12 | SCENE= }}
{{STRUCTURE_1q12| PDB=1q12 | SCENE= }}
-
'''Crystal Structure of the ATP-bound E. coli MalK'''
+
===Crystal Structure of the ATP-bound E. coli MalK===
-
==Overview==
+
<!--
-
The ATPase components of ATP binding cassette (ABC) transporters power the transporters by binding and hydrolyzing ATP. Major conformational changes of an ATPase are revealed by crystal structures of MalK, the ATPase subunit of the maltose transporter from Escherichia coli, in three different dimeric configurations. While other nucleotide binding domains or subunits display low affinity for each other in the absence of the transmembrane segments, the MalK dimer is stabilized through interactions of the additional C-terminal domains. In the two nucleotide-free structures, the N-terminal nucleotide binding domains are separated to differing degrees, and the dimer is maintained through contacts of the C-terminal regulatory domains. In the ATP-bound form, the nucleotide binding domains make contact and two ATPs lie buried along the dimer interface. The two nucleotide binding domains of the dimer open and close like a pair of tweezers, suggesting a regulatory mechanism for ATPase activity that may be tightly coupled to translocation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14527411}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14527411 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14527411}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
[[Category: Atp-binding cassette]]
[[Category: Atp-binding cassette]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:44:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:26:02 2008''

Revision as of 08:26, 29 July 2008

Image:1q12.png

Template:STRUCTURE 1q12

Crystal Structure of the ATP-bound E. coli MalK

Template:ABSTRACT PUBMED 14527411

About this Structure

1Q12 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle., Chen J, Lu G, Lin J, Davidson AL, Quiocho FA, Mol Cell. 2003 Sep;12(3):651-61. PMID:14527411

Page seeded by OCA on Tue Jul 29 11:26:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1q12"
Personal tools