1qgt

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[[Image:1qgt.gif|left|200px]]
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{{STRUCTURE_1qgt| PDB=1qgt | SCENE= }}
{{STRUCTURE_1qgt| PDB=1qgt | SCENE= }}
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'''HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)'''
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===HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)===
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==Overview==
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Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The crystal structure of the T = 4 capsid has been solved at 3.3 A resolution, revealing a largely helical protein fold that is unusual for icosahedral viruses. The monomer fold is stabilized by a hydrophobic core that is highly conserved among human viral variants. Association of two amphipathic alpha-helical hairpins results in formation of a dimer with a four-helix bundle as the major central feature. The capsid is assembled from dimers via interactions involving a highly conserved region near the C terminus of the truncated protein used for crystallization. The major immunodominant region lies at the tips of the alpha-helical hairpins that form spikes on the capsid surface.
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The line below this paragraph, {{ABSTRACT_PUBMED_10394365}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10394365 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10394365}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Viral capsid protein]]
[[Category: Viral capsid protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:15:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:29:07 2008''

Revision as of 08:29, 29 July 2008

Image:1qgt.png

Template:STRUCTURE 1qgt

HUMAN HEPATITIS B VIRAL CAPSID (HBCAG)

Template:ABSTRACT PUBMED 10394365

About this Structure

1QGT is a Single protein structure of sequence from Hepatitis b virus. Full crystallographic information is available from OCA.

Reference

The crystal structure of the human hepatitis B virus capsid., Wynne SA, Crowther RA, Leslie AG, Mol Cell. 1999 Jun;3(6):771-80. PMID:10394365

Page seeded by OCA on Tue Jul 29 11:29:07 2008

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