1pwv
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(New page: 200px<br /><applet load="1pwv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pwv, resolution 2.85Å" /> '''Crystal structure of...)
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Revision as of 22:04, 20 November 2007
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Crystal structure of Anthrax Lethal Factor wild-type protein complexed with an optimised peptide substrate.
Overview
Recent events have created an urgent need for new therapeutic strategies, to treat anthrax. We have applied a mixture-based peptide library approach, to rapidly determine the optimal peptide substrate for the anthrax lethal, factor (LF), a metalloproteinase with an important role in the, pathogenesis of the disease. Using this approach we have identified, peptide analogs that inhibit the enzyme in vitro and that protect cultured, macrophages from LF-mediated cytolysis. The crystal structures of LF bound, to an optimized peptide substrate and to peptide-based inhibitors provide, a rationale for the observed selectivity and may be exploited in the, design of future generations of LF inhibitors.
About this Structure
1PWV is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.
Reference
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor., Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC, Nat Struct Mol Biol. 2004 Jan;11(1):60-6. Epub 2003 Dec 29. PMID:14718924
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