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1rk7

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[[Image:1rk7.jpg|left|200px]]
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{{STRUCTURE_1rk7| PDB=1rk7 | SCENE= }}
{{STRUCTURE_1rk7| PDB=1rk7 | SCENE= }}
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'''Solution structure of apo Cu,Zn Superoxide Dismutase: role of metal ions in protein folding'''
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===Solution structure of apo Cu,Zn Superoxide Dismutase: role of metal ions in protein folding===
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==Overview==
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The solution structure of the demetalated copper, zinc superoxide dismutase is obtained for the monomeric Glu133Gln/Phe50Glu/Gly51Glu mutant through NMR spectroscopy. The demetalated protein still has a well-defined tertiary structure; however, two beta-strands containing two copper ligands (His46 and His48, beta4) and one zinc ligand (Asp83, beta5) are shortened, and the sheet formed by these strands and strands beta7 and beta8 moves away from the other strands of the beta-barrel to form an open clam with respect to a closed conformation in the holoprotein. Furthermore, loop IV which contains three zinc ligands (His63, His71, and His80) and loop VII which contributes to the definition of the active cavity channel are severely disordered, and experience extensive mobility as it results from thorough (15)N relaxation measurements. These structural and mobility data, if compared with those of the copper-depleted protein and holoprotein, point out the role of each metal ion in the protein folding, leading to the final tertiary structure of the holoprotein, and provide hints for the mechanisms of metal delivery by metal chaperones.
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The line below this paragraph, {{ABSTRACT_PUBMED_12911296}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12911296 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12911296}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1RK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RK7 OCA].
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1RK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RK7 OCA].
==Reference==
==Reference==
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[[Category: Q133m2sod]]
[[Category: Q133m2sod]]
[[Category: Solution structure]]
[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:35:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:32:58 2008''

Revision as of 08:33, 29 July 2008

Image:1rk7.png

Template:STRUCTURE 1rk7

Contents

Solution structure of apo Cu,Zn Superoxide Dismutase: role of metal ions in protein folding

Template:ABSTRACT PUBMED 12911296

Disease

Known disease associated with this structure: Amyotrophic lateral sclerosis, due to SOD1 deficiency OMIM:[147450]

About this Structure

1RK7 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding., Banci L, Bertini I, Cramaro F, Del Conte R, Viezzoli MS, Biochemistry. 2003 Aug 19;42(32):9543-53. PMID:12911296

Page seeded by OCA on Tue Jul 29 11:32:58 2008

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