1opy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1opy.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1opy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1opy| PDB=1opy | SCENE= }}
{{STRUCTURE_1opy| PDB=1opy | SCENE= }}
-
'''KSI'''
+
===KSI===
-
==Overview==
+
<!--
-
The three-dimensional structure of the enzyme 3-oxo-delta5-steroid isomerase (E.C. 5.3.3.1), a 28-kilodalton symmetrical dimer, was solved by multidimensional heteronuclear magnetic resonance spectroscopy. The two independently folded monomers pack together by means of extensive hydrophobic and electrostatic interactions. Each monomer comprises three alpha helices and a six-strand mixed beta-pleated sheet arranged to form a deep hydrophobic cavity. Catalytically important residues Tyr14 (general acid) and Asp38 (general base) are located near the bottom of the cavity and positioned as expected from mechanistic hypotheses. An unexpected acid group (Asp99) is also located in the active site adjacent to Tyr14, and kinetic and binding studies of the Asp99 to Ala mutant demonstrate that Asp99 contributes to catalysis by stabilizing the intermediate.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9103200}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9103200 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9103200}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Low-barrier hydrogen bond]]
[[Category: Low-barrier hydrogen bond]]
[[Category: Pseudomonas putida biotype b]]
[[Category: Pseudomonas putida biotype b]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:08:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:33:34 2008''

Revision as of 08:33, 29 July 2008

Image:1opy.png

Template:STRUCTURE 1opy

KSI

Template:ABSTRACT PUBMED 9103200

About this Structure

1OPY is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Solution structure of 3-oxo-delta5-steroid isomerase., Wu ZR, Ebrahimian S, Zawrotny ME, Thornburg LD, Perez-Alvarado GC, Brothers P, Pollack RM, Summers MF, Science. 1997 Apr 18;276(5311):415-8. PMID:9103200

Page seeded by OCA on Tue Jul 29 11:33:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1opy"
Personal tools