1p8z

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[[Image:1p8z.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1p8z| PDB=1p8z | SCENE= }}
{{STRUCTURE_1p8z| PDB=1p8z | SCENE= }}
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'''Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156'''
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===Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156===
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==Overview==
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We present the 2.6 A resolution crystal structure of a complex formed between G-actin and gelsolin fragment Met25-Gln160 (G1+). The structure differs from those of other gelsolin domain 1 (G1) complexes in that an additional six amino acid residues from the crucial linker region into gelsolin domain 2 (G2) are visible and are attached securely to the surface of actin. The linker segment extends away from G1 up the face of actin in a direction that infers G2 will bind along the same long-pitch helical strand as the actin bound to G1. This is consistent with a mechanism whereby G2 attaches gelsolin to the side of a filament and then directs G1 toward a position where it would disrupt actin-actin contacts. Alignment of the sequence of the structurally important residues within the G1-G2 linker with those of WH2 (WASp homology domain 2) domain protein family members (e.g. WASp (Wiscott-Aldridge syndrome protein) and thymosin beta4) suggests that the opposing activities of filament assembly and disassembly may exploit a common patch on the surface of actin.
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The line below this paragraph, {{ABSTRACT_PUBMED_14527665}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14527665 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14527665}}
==About this Structure==
==About this Structure==
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[[Category: Robinson, R C.]]
[[Category: Robinson, R C.]]
[[Category: Linker between gelsolin domain 1 and domain 2]]
[[Category: Linker between gelsolin domain 1 and domain 2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:50:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:39:11 2008''

Revision as of 08:39, 29 July 2008

Image:1p8z.png

Template:STRUCTURE 1p8z

Complex Between Rabbit Muscle alpha-Actin: Human Gelsolin Residues Val26-Glu156

Template:ABSTRACT PUBMED 14527665

About this Structure

1P8Z is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

From the first to the second domain of gelsolin: a common path on the surface of actin?, Irobi E, Burtnick LD, Urosev D, Narayan K, Robinson RC, FEBS Lett. 2003 Sep 25;552(2-3):86-90. PMID:14527665

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