2bct

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[[Image:2bct.gif|left|200px]]
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{{STRUCTURE_2bct| PDB=2bct | SCENE= }}
{{STRUCTURE_2bct| PDB=2bct | SCENE= }}
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'''THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN'''
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===THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN===
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==Overview==
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Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). A core region of beta-catenin, composed of 12 copies of a 42 amino acid sequence motif known as an armadillo repeat, mediates these interactions. The three-dimensional structure of a protease-resistant fragment of beta-catenin containing the armadillo repeat region has been determined. The 12 repeats form a superhelix of helices that features a long, positively charged groove. Although unrelated in sequence, the beta-catenin binding regions of cadherins, Tcfs, and APC are acidic and are proposed to interact with this groove.
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(as it appears on PubMed at http://www.pubmed.gov), where 9298899 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9298899}}
==About this Structure==
==About this Structure==
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[[Category: Beta-catenin]]
[[Category: Beta-catenin]]
[[Category: Structural protein]]
[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:07:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:42:29 2008''

Revision as of 08:42, 29 July 2008

Image:2bct.png

Template:STRUCTURE 2bct

THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

Template:ABSTRACT PUBMED 9298899

About this Structure

2BCT is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the armadillo repeat region of beta-catenin., Huber AH, Nelson WJ, Weis WI, Cell. 1997 Sep 5;90(5):871-82. PMID:9298899

Page seeded by OCA on Tue Jul 29 11:42:29 2008

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