1zcj

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[[Image:1zcj.gif|left|200px]]
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{{STRUCTURE_1zcj| PDB=1zcj | SCENE= }}
{{STRUCTURE_1zcj| PDB=1zcj | SCENE= }}
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'''Crystal structure of 3-hydroxyacyl-CoA dehydrogenase'''
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===Crystal structure of 3-hydroxyacyl-CoA dehydrogenase===
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==Overview==
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The 1.9 A structure of the C-terminal dehydrogenase part of the rat peroxisomal monomeric multifunctional enzyme type 1 (MFE-1) has been determined. In this construct (residues 260-722 and referred to as MFE1-DH) the N-terminal hydratase part of MFE-1 has been deleted. The structure of MFE1-DH shows that it consists of an N-terminal helix, followed by a Rossmann-fold domain (domain C), followed by two tightly associated helical domains (domains D and E), which have similar topology. The structure of MFE1-DH is compared with the two known homologous structures: human mitochondrial 3-hydroxyacyl-CoA dehydrogenase (HAD; sequence identity is 33%) (which is dimeric and monofunctional) and with the dimeric multifunctional alpha-chain (alphaFOM; sequence identity is 28%) of the bacterial fatty acid beta-oxidation alpha2beta2-multienzyme complex. Like MFE-1, alphaFOM has an N-terminal hydratase part and a C-terminal dehydrogenase part, and the structure comparisons show that the N-terminal helix of MFE1-DH corresponds to the alphaFOM linker helix, located between its hydratase and dehydrogenase part. It is also shown that this helix corresponds to the C-terminal helix-10 of the hydratase/isomerase superfamily, suggesting that functionally it belongs to the N-terminal hydratase part of MFE-1.
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(as it appears on PubMed at http://www.pubmed.gov), where 16330050 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16330050}}
==About this Structure==
==About this Structure==
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[[Category: Peroxisomal multifunctional enzyme type 1]]
[[Category: Peroxisomal multifunctional enzyme type 1]]
[[Category: Rat]]
[[Category: Rat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:27:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:48:03 2008''

Revision as of 08:48, 29 July 2008

Image:1zcj.png

Template:STRUCTURE 1zcj

Crystal structure of 3-hydroxyacyl-CoA dehydrogenase

Template:ABSTRACT PUBMED 16330050

About this Structure

1ZCJ is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural studies of MFE-1: the 1.9 A crystal structure of the dehydrogenase part of rat peroxisomal MFE-1., Taskinen JP, Kiema TR, Hiltunen JK, Wierenga RK, J Mol Biol. 2006 Jan 27;355(4):734-46. Epub 2005 Nov 18. PMID:16330050

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