2nzh

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{{STRUCTURE_2nzh| PDB=2nzh | SCENE= }}
{{STRUCTURE_2nzh| PDB=2nzh | SCENE= }}
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'''Crystal structure of a secretion chaperone CsaA from Bacillus subtilis in the space group P 4 21 2'''
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===Crystal structure of a secretion chaperone CsaA from Bacillus subtilis in the space group P 4 21 2===
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==Overview==
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Bacillus subtilis CsaA (BsCsaA) has been proposed to act as a protein-secretion chaperone in the Sec-dependent translocation pathway, possibly compensating for the lack of SecB in the Gram-positive eubacterium Bacillus subtilis. This paper presents the cloning, purification, crystallization and structures of BsCsaA in two space groups (P42(1)2 and P3(2)21) solved and refined to resolutions of 1.9 and 2.0 A, respectively. These structures complement the previously available crystal structure of CsaA from the Gram-negative eubacterium Thermus thermophilus (TtCsaA) and provide a direct structural basis for the interpretation of previously available biochemical data on BsCsaA. The sequence and structure of the proposed substrate-binding pocket are analyzed and discussed. A comparison with the TtCsaA structure reveals a different pattern of electrostatic potential in the vicinity of the binding site, which overlaps with a region of high sequence variability. In addition, the dimerization interface of this homodimeric protein is analyzed and discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 17372352 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17372352}}
==About this Structure==
==About this Structure==
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[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Oligonucleotide/oligosaccharide binding fold]]
[[Category: Oligonucleotide/oligosaccharide binding fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:07:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:48:30 2008''

Revision as of 08:48, 29 July 2008

Image:2nzh.png

Template:STRUCTURE 2nzh

Crystal structure of a secretion chaperone CsaA from Bacillus subtilis in the space group P 4 21 2

Template:ABSTRACT PUBMED 17372352

About this Structure

2NZH is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystallographic analysis of Bacillus subtilis CsaA., Shapova YA, Paetzel M, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):478-85. Epub 2007, Mar 16. PMID:17372352

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