1muq

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{{STRUCTURE_1muq| PDB=1muq | SCENE= }}
{{STRUCTURE_1muq| PDB=1muq | SCENE= }}
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'''X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside'''
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===X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside===
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==Overview==
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Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15049685}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15049685 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15049685}}
==About this Structure==
==About this Structure==
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[[Category: Decamer]]
[[Category: Decamer]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:44:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:49:42 2008''

Revision as of 08:49, 29 July 2008

Image:1muq.png

Template:STRUCTURE 1muq

X-ray Crystal Structure of Rattlesnake Venom Complexed With Thiodigalactoside

Template:ABSTRACT PUBMED 15049685

About this Structure

1MUQ is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:15049685

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