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1ysv

From Proteopedia

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[[Image:1ysv.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ysv| PDB=1ysv | SCENE= }}
{{STRUCTURE_1ysv| PDB=1ysv | SCENE= }}
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'''Solution structure of the central region of the human GluR-B R/G pre-mRNA'''
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===Solution structure of the central region of the human GluR-B R/G pre-mRNA===
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==Overview==
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Adenosine deaminases that act on RNA (ADARs) catalyze the site-specific conversion of adenosine to inosine in primary mRNA transcripts, thereby affecting coding potential of mature mRNAs. Structural determinants that define the adenosine moieties for specific ADARs-mediated deaminations are currently unknown. We report the solution structure of the central region of the human R/G stem-loop pre-mRNA, a natural ADAR2 substrate encoding the subunit B of the glutamate receptor (R/G site). The structure reveals that the GCU(A/C)A pentaloop that is conserved in mammals and birds adopts a novel fold. The fold is stabilized by a complex interplay of hydrogen bonds and stacking interactions. We propose that this new pentaloop structure is an important determinant of the R/G site recognition by ADAR2.
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The line below this paragraph, {{ABSTRACT_PUBMED_15840813}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15840813 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15840813}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YSV OCA].
==Reference==
==Reference==
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[[Category: Stem-loop]]
[[Category: Stem-loop]]
[[Category: Structure]]
[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:44:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:52:31 2008''

Revision as of 08:52, 29 July 2008

Image:1ysv.png

Template:STRUCTURE 1ysv

Solution structure of the central region of the human GluR-B R/G pre-mRNA

Template:ABSTRACT PUBMED 15840813

About this Structure

Full experimental information is available from OCA.

Reference

A novel RNA pentaloop fold involved in targeting ADAR2., Stefl R, Allain FH, RNA. 2005 May;11(5):592-7. PMID:15840813

Page seeded by OCA on Tue Jul 29 11:52:31 2008

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