1yzc

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[[Image:1yzc.gif|left|200px]]
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{{Seed}}
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[[Image:1yzc.png|left|200px]]
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{{STRUCTURE_1yzc| PDB=1yzc | SCENE= }}
{{STRUCTURE_1yzc| PDB=1yzc | SCENE= }}
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'''The solution structure of a redesigned apocytochrome B562 (Rd-apocyt b562) with the N- and a part of the C-terminal helices unfolded'''
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===The solution structure of a redesigned apocytochrome B562 (Rd-apocyt b562) with the N- and a part of the C-terminal helices unfolded===
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==Overview==
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Using native-state hydrogen-exchange-directed protein engineering and multidimensional NMR, we determined the high-resolution structure (rms deviation, 1.1 angstroms) for an intermediate of the four-helix bundle protein: Rd-apocytochrome b562. The intermediate has the N-terminal helix and a part of the C-terminal helix unfolded. In earlier studies, we also solved the structures of two other folding intermediates for the same protein: one with the N-terminal helix alone unfolded and the other with a reorganized hydrophobic core. Together, these structures provide a description of a protein folding pathway with multiple intermediates at atomic resolution. The two general features for the intermediates are (i) native-like backbone topology and (ii) nonnative side-chain interactions. These results have implications for important issues in protein folding studies, including large-scale conformation search, -value analysis, and computer simulations.
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The line below this paragraph, {{ABSTRACT_PUBMED_15793003}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15793003 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15793003}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZC OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZC OCA].
==Reference==
==Reference==
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[[Category: Psi]]
[[Category: Psi]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:59:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:52:34 2008''

Revision as of 08:52, 29 July 2008

Image:1yzc.png

Template:STRUCTURE 1yzc

The solution structure of a redesigned apocytochrome B562 (Rd-apocyt b562) with the N- and a part of the C-terminal helices unfolded

Template:ABSTRACT PUBMED 15793003

About this Structure

Full experimental information is available from OCA.

Reference

A protein folding pathway with multiple folding intermediates at atomic resolution., Feng H, Zhou Z, Bai Y, Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5026-31. Epub 2005 Mar 25. PMID:15793003

Page seeded by OCA on Tue Jul 29 11:52:34 2008

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