2c5i

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[[Image:2c5i.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2c5i| PDB=2c5i | SCENE= }}
{{STRUCTURE_2c5i| PDB=2c5i | SCENE= }}
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'''N-TERMINAL DOMAIN OF TLG1 COMPLEXED WITH N-TERMINUS OF VPS51 IN DISTORTED CONFORMATION'''
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===N-TERMINAL DOMAIN OF TLG1 COMPLEXED WITH N-TERMINUS OF VPS51 IN DISTORTED CONFORMATION===
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==Overview==
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Membrane fusion in cells involves the interaction of SNARE proteins on apposing membranes. Formation of SNARE complexes is preceded by tethering events, and a number of protein complexes that are thought to mediate this have been identified. The VFT or GARP complex is required for endosome-Golgi traffic in yeast. It consists of four subunits, one of which, Vps51, has been shown to bind specifically to the SNARE Tlg1, which participates in the same fusion event. We have determined the structure of the N-terminal domain of Tlg1 bound to a peptide from the N terminus of Vps51. Binding depends mainly on residues 18-30 of Vps51. These form a short helix which lies in a conserved groove in the three-helix bundle formed by Tlg1. Surprisingly, although both Vps51 and Tlg1 are required for transport to the late Golgi from endosomes, removal of the Tlg1-binding sequences from Vps51 does not block such traffic in vivo. Thus, this particular interaction cannot be crucial to the process of vesicle docking or fusion.
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(as it appears on PubMed at http://www.pubmed.gov), where 16420526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16420526}}
==About this Structure==
==About this Structure==
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[[Category: Snare]]
[[Category: Snare]]
[[Category: Vft complex]]
[[Category: Vft complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:17:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:53:59 2008''

Revision as of 08:54, 29 July 2008

Image:2c5i.png

Template:STRUCTURE 2c5i

N-TERMINAL DOMAIN OF TLG1 COMPLEXED WITH N-TERMINUS OF VPS51 IN DISTORTED CONFORMATION

Template:ABSTRACT PUBMED 16420526

About this Structure

2C5I is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural analysis of the interaction between the SNARE Tlg1 and Vps51., Fridmann-Sirkis Y, Kent HM, Lewis MJ, Evans PR, Pelham HR, Traffic. 2006 Feb;7(2):182-90. PMID:16420526

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