1phr

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{{STRUCTURE_1phr| PDB=1phr | SCENE= }}
{{STRUCTURE_1phr| PDB=1phr | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE'''
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===THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE===
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==Overview==
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Protein tyrosine phosphorylation and dephosphorylation are central reactions for control of cellular division, differentiation and development. Here we describe the crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase (PTPase), a cytosolic phosphatase present in many mammalian cells. The enzyme catalyses the dephosphorylation of phosphotyrosine-containing substrates, and overexpression of the protein in normal and transformed cells inhibits cell proliferation. The structure of the low-molecular-weight PTPase reveals an alpha/beta protein containing a phosphate-binding loop motif at the amino end of helix alpha 1. This motif includes the essential active-site residues Cys 12 and Arg 18 and bears striking similarities to the active-site motif recently described in the structure of human PTP1B. The structure of the low-molecular-weight PTPase supports a reaction mechanism involving the conserved Cys 12 as an attacking nucleophile in an in-line associative mechanism. The structure also suggests a catalytic role for Asp 129 in the reaction cycle.
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(as it appears on PubMed at http://www.pubmed.gov), where 8052313 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8052313}}
==About this Structure==
==About this Structure==
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[[Category: Taddei, N.]]
[[Category: Taddei, N.]]
[[Category: Phosphotyrosine protein phosphatase]]
[[Category: Phosphotyrosine protein phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:06:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:54:42 2008''

Revision as of 08:54, 29 July 2008

Image:1phr.png

Template:STRUCTURE 1phr

THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE

Template:ABSTRACT PUBMED 8052313

About this Structure

1PHR is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase., Su XD, Taddei N, Stefani M, Ramponi G, Nordlund P, Nature. 1994 Aug 18;370(6490):575-8. PMID:8052313

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