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1t44

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{{STRUCTURE_1t44| PDB=1t44 | SCENE= }}
{{STRUCTURE_1t44| PDB=1t44 | SCENE= }}
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'''Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation'''
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===Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation===
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==Overview==
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The WH2 (Wiscott-Aldridge syndrome protein homology domain 2) repeat is an actin interacting motif found in monomer sequestering and filament assembly proteins. We have stabilized the prototypical WH2 family member, thymosin-beta4 (Tbeta4), with respect to actin, by creating a hybrid between gelsolin domain 1 and the C-terminal half of Tbeta4 (G1-Tbeta4). This hybrid protein sequesters actin monomers, severs actin filaments and acts as a leaky barbed end cap. Here, we present the structure of the G1-Tbeta4:actin complex at 2 A resolution. The structure reveals that Tbeta4 sequesters by capping both ends of the actin monomer, and that exchange of actin between Tbeta4 and profilin is mediated by a minor overlap in binding sites. The structure implies that multiple WH2 motif-containing proteins will associate longitudinally with actin filaments. Finally, we discuss the role of the WH2 motif in arp2/3 activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 15329672 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15329672}}
==About this Structure==
==About this Structure==
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[[Category: Robinson, R C.]]
[[Category: Robinson, R C.]]
[[Category: Structural protein]]
[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:29:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:54:49 2008''

Revision as of 08:54, 29 July 2008

Image:1t44.png

Template:STRUCTURE 1t44

Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation

Template:ABSTRACT PUBMED 15329672

About this Structure

1T44 is a Protein complex structure of sequences from Homo sapiens, mus musculus and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins., Irobi E, Aguda AH, Larsson M, Guerin C, Yin HL, Burtnick LD, Blanchoin L, Robinson RC, EMBO J. 2004 Sep 15;23(18):3599-608. Epub 2004 Aug 26. PMID:15329672

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