1wm4

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{{STRUCTURE_1wm4| PDB=1wm4 | SCENE= }}
{{STRUCTURE_1wm4| PDB=1wm4 | SCENE= }}
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'''Solution structure of mouse coactosin, an actin filament binding protein'''
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===Solution structure of mouse coactosin, an actin filament binding protein===
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==Overview==
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Coactosin is a small (MW approximately 15 kDa) evolutionarily conserved actin filament binding protein. It displays remote sequence homology to ADF/cofilin proteins and to the ADF-H domains of twinfilin and Abp1/drebrin. However, biochemical analyses have demonstrated that coactosin has a very different role in actin dynamics from the ones of ADF/cofilin, twinfilin or Abp1/drebrin. To elucidate the molecular mechanism of coactosin/actin interaction, we determined the three-dimensional structure of mouse coactosin by multidimensional NMR spectroscopy. We find that the coactosin structure is homologous to ADF/cofilin and to the ADF-H domains of twinfilin. Furthermore, the regions that have been shown to be important for actin filament interactions in ADF/cofilins are structurally conserved in coactosin suggesting that these two proteins interact with F-actin through a conserved interface. Our analysis also identifies key structural differences between these proteins that may account for the differences in biochemical activities and cellular roles of these proteins.
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{{ABSTRACT_PUBMED_15474017}}
==About this Structure==
==About this Structure==
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1WM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM4 OCA].
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1WM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WM4 OCA].
==Reference==
==Reference==
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[[Category: Permi, P.]]
[[Category: Permi, P.]]
[[Category: Adf-h domain]]
[[Category: Adf-h domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:51:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:56:55 2008''

Revision as of 08:56, 29 July 2008

Image:1wm4.png

Template:STRUCTURE 1wm4

Solution structure of mouse coactosin, an actin filament binding protein

Template:ABSTRACT PUBMED 15474017

About this Structure

1WM4 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins., Hellman M, Paavilainen VO, Naumanen P, Lappalainen P, Annila A, Permi P, FEBS Lett. 2004 Oct 8;576(1-2):91-6. PMID:15474017

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