2pzx

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{{STRUCTURE_2pzx| PDB=2pzx | SCENE= }}
{{STRUCTURE_2pzx| PDB=2pzx | SCENE= }}
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'''Structure of the methuselah ectodomain with peptide inhibitor'''
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===Structure of the methuselah ectodomain with peptide inhibitor===
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==Overview==
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G protein-coupled receptors (GPCRs) mediate signaling from extracellular ligands to intracellular signal transduction proteins. Methuselah (Mth) is a class B (secretin-like) GPCR, a family typified by their large, ligand-binding, N-terminal extracellular domains. Downregulation of mth increases the life span of Drosophila melanogaster; inhibitors of Mth signaling should therefore enhance longevity. We used mRNA display selection to identify high-affinity (K(d) = 15 to 30 nM) peptide ligands that bind to the N-terminal ectodomain of Mth. The selected peptides are potent antagonists of Mth signaling, and structural studies suggest that they perturb the interface between the Mth ecto- and transmembrane domains. Flies constitutively expressing a Mth antagonist peptide have a robust life span extension, which suggests that the peptides inhibit Mth signaling in vivo. Our work thus provides new life span-extending ligands for a metazoan and a general approach for the design of modulators of this important class of GPCRs.
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(as it appears on PubMed at http://www.pubmed.gov), where 17546039 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17546039}}
==About this Structure==
==About this Structure==
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[[Category: Gpcr g protein-coupled receptor ectodomain]]
[[Category: Gpcr g protein-coupled receptor ectodomain]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:05:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:57:48 2008''

Revision as of 08:57, 29 July 2008

Image:2pzx.png

Template:STRUCTURE 2pzx

Structure of the methuselah ectodomain with peptide inhibitor

Template:ABSTRACT PUBMED 17546039

About this Structure

2PZX is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor., Ja WW, West AP Jr, Delker SL, Bjorkman PJ, Benzer S, Roberts RW, Nat Chem Biol. 2007 Jul;3(7):415-9. Epub 2007 Jun 3. PMID:17546039

Page seeded by OCA on Tue Jul 29 11:57:48 2008

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