1zl7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zl7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1zl7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zl7| PDB=1zl7 | SCENE= }}
{{STRUCTURE_1zl7| PDB=1zl7 | SCENE= }}
-
'''Crystal structure of catalytically-active phospholipase A2 with bound calcium'''
+
===Crystal structure of catalytically-active phospholipase A2 with bound calcium===
-
==Overview==
+
<!--
-
The electrophile Ca(2+) is an essential multifunctional co-factor in the phospholipase A(2) mediated hydrolysis of phospholipids. Crystal structures of an acidic phospholipase A(2) from the venom of Bothrops jararacussu have been determined both in the Ca(2+) free and bound states at 0.97 and 1.60 A resolutions, respectively. In the Ca(2+) bound state, the Ca(2+) ion is penta-coordinated by a distorted pyramidal cage of oxygen and nitrogen atoms that is significantly different to that observed in structures of other Group I/II phospholipases A(2). In the absence of Ca(2+), a water molecule occupies the position of the Ca(2+) ion and the side chain of Asp49 and the calcium-binding loop adopts a different conformation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16376474}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16376474 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16376474}}
==About this Structure==
==About this Structure==
Line 20: Line 24:
==Reference==
==Reference==
Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376474 16376474]
Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376474 16376474]
 +
 +
Crystallization and high-resolution X-ray diffraction data collection of an Asp49 PLA2 from Bothrops jararacussu venom both in the presence and absence of Ca2+ ions., Murakami MT, Michelan-Duarte S, Cintra AC, Arni RK, Biochim Biophys Acta. 2004 Dec 1;1703(1):79-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15588705 15588705]
[[Category: Bothrops jararacussu]]
[[Category: Bothrops jararacussu]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 30: Line 36:
[[Category: Asp49-pla2]]
[[Category: Asp49-pla2]]
[[Category: Snake venom]]
[[Category: Snake venom]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:45:42 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:58:19 2008''

Revision as of 08:58, 29 July 2008

Image:1zl7.png

Template:STRUCTURE 1zl7

Crystal structure of catalytically-active phospholipase A2 with bound calcium

Template:ABSTRACT PUBMED 16376474

About this Structure

1ZL7 is a Single protein structure of sequence from Bothrops jararacussu. Full crystallographic information is available from OCA.

Reference

Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:16376474

Crystallization and high-resolution X-ray diffraction data collection of an Asp49 PLA2 from Bothrops jararacussu venom both in the presence and absence of Ca2+ ions., Murakami MT, Michelan-Duarte S, Cintra AC, Arni RK, Biochim Biophys Acta. 2004 Dec 1;1703(1):79-81. PMID:15588705

Page seeded by OCA on Tue Jul 29 11:58:19 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zl7"
Personal tools