2ao5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ao5.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ao5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ao5| PDB=2ao5 | SCENE= }}
{{STRUCTURE_2ao5| PDB=2ao5 | SCENE= }}
-
'''Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs'''
+
===Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs===
-
==Overview==
+
<!--
-
The crystal structure of a self-complementary RNA duplex r(GGCG(Br)UGCGCU)(2) with terminal G.U and internal tandem G.U base pairs has been determined at 2.1 Angstroms resolution. The crystals belong to the tetragonal space group P4(3), with unit-cell parameters a = b = 37.69, c = 96.28 Angstroms and two duplexes in the asymmetric unit. The two strands of each duplex are related by a pseudodyad axis. The structure was refined to final R(work) and R(free) values of 20.9 and 25.3%, respectively. The duplexes stack in an end-to-end manner, forming infinite columns along the c axis. This is the first structural study of an RNA duplex containing G.U pairs at the termini. The stacking overlaps of the terminal G.U base pairs with their adjacent Watson-Crick base pairs are larger than those of Watson-Crick base pairs of the 5'-YR-3'/3'-RY-5' type. The terminal G.U base pairs of neighbouring duplexes are also stacked with each other. An alternating underwound-overwound pattern of the twist angles is seen at each step along the duplex. This observation is typical for internal tandem G.U pairs, while the terminal G.U base pairs exhibit high twist angles with the adjacent Watson-Crick pairs. The 3'-side of U of the internal G.U base pair, which is unstacked, appears to be stabilized by pi-cation interaction with an Mg(2+) ion.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16510980}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16510980 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16510980}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: G-u base pair]]
[[Category: G-u base pair]]
[[Category: Rna duplex]]
[[Category: Rna duplex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:16:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:00:55 2008''

Revision as of 09:00, 29 July 2008

Image:2ao5.png

Template:STRUCTURE 2ao5

Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs

Template:ABSTRACT PUBMED 16510980

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G.U base pairs., Utsunomiya R, Suto K, Balasundaresan D, Fukamizu A, Kumar PK, Mizuno H, Acta Crystallogr D Biol Crystallogr. 2006 Mar;62(Pt 3):331-8. Epub 2006, Feb 22. PMID:16510980

Page seeded by OCA on Tue Jul 29 12:00:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ao5"
Personal tools