3bb7

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{{STRUCTURE_3bb7| PDB=3bb7 | SCENE= }}
{{STRUCTURE_3bb7| PDB=3bb7 | SCENE= }}
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'''Structure of Prevotella intermedia prointerpain A fragment 39-359 (mutant C154A)'''
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===Structure of Prevotella intermedia prointerpain A fragment 39-359 (mutant C154A)===
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==Overview==
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Prevotella intermedia is a major periodontopathogen contributing to human gingivitis and periodontitis. Such pathogens release proteases as virulence factors that cause deterrence of host defenses and tissue destruction. A new cysteine protease from the cysteine-histidine-dyad class, interpain A, was studied in its zymogenic and self-processed mature forms. The latter consists of a bivalved moiety made up by two subdomains. In the structure of a catalytic cysteine-to-alanine zymogen variant, the right subdomain interacts with an unusual prodomain, thus contributing to latency. Unlike the catalytic cysteine residue, already in its competent conformation in the zymogen, the catalytic histidine is swung out from its active conformation and trapped in a cage shaped by a backing helix, a zymogenic hairpin, and a latency flap in the zymogen. Dramatic rearrangement of up to 20A of these elements triggered by a tryptophan switch occurs during activation and accounts for a new activation mechanism for proteolytic enzymes. These findings can be extrapolated to related potentially pathogenic cysteine proteases such as Streprococcus pyogenes SpeB and Porphyromonas gingivalis periodontain.
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(as it appears on PubMed at http://www.pubmed.gov), where 17993455 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17993455}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Zymogen activation]]
[[Category: Zymogen activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:36:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:03:31 2008''

Revision as of 09:03, 29 July 2008

Image:3bb7.png

Template:STRUCTURE 3bb7

Structure of Prevotella intermedia prointerpain A fragment 39-359 (mutant C154A)

Template:ABSTRACT PUBMED 17993455

About this Structure

3BB7 is a Single protein structure of sequence from Prevotella intermedia. Full crystallographic information is available from OCA.

Reference

A New Autocatalytic Activation Mechanism for Cysteine Proteases Revealed by Prevotella intermedia Interpain A., Mallorqui-Fernandez N, Manandhar SP, Mallorqui-Fernandez G, Uson I, Wawrzonek K, Kantyka T, Sola M, Thogersen IB, Enghild JJ, Potempa J, Gomis-Ruth FX, J Biol Chem. 2008 Feb 1;283(5):2871-82. Epub 2007 Nov 9. PMID:17993455

Page seeded by OCA on Tue Jul 29 12:03:31 2008

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