1yfj

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[[Image:1yfj.gif|left|200px]]
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{{Seed}}
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[[Image:1yfj.png|left|200px]]
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{{STRUCTURE_1yfj| PDB=1yfj | SCENE= }}
{{STRUCTURE_1yfj| PDB=1yfj | SCENE= }}
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'''T4Dam in Complex with AdoHcy and 15-mer Oligonucleotide Showing Semi-specific and Specific Contact'''
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===T4Dam in Complex with AdoHcy and 15-mer Oligonucleotide Showing Semi-specific and Specific Contact===
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==Overview==
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DNA methyltransferases methylate target bases within specific nucleotide sequences. Three structures are described for bacteriophage T4 DNA-adenine methyltransferase (T4Dam) in ternary complexes with partially and fully specific DNA and a methyl-donor analog. We also report the effects of substitutions in the related Escherichia coli DNA methyltransferase (EcoDam), altering residues corresponding to those involved in specific interaction with the canonical GATC target sequence in T4Dam. We have identified two types of protein-DNA interactions: discriminatory contacts, which stabilize the transition state and accelerate methylation of the cognate site, and antidiscriminatory contacts, which do not significantly affect methylation of the cognate site but disfavor activity at noncognate sites. These structures illustrate the transition in enzyme-DNA interaction from nonspecific to specific interaction, suggesting that there is a temporal order for formation of specific contacts.
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The line below this paragraph, {{ABSTRACT_PUBMED_15882618}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15882618 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15882618}}
==About this Structure==
==About this Structure==
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[[Category: Methyltransferase]]
[[Category: Methyltransferase]]
[[Category: T4dam]]
[[Category: T4dam]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:15:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:07:01 2008''

Revision as of 09:07, 29 July 2008

Image:1yfj.png

Template:STRUCTURE 1yfj

T4Dam in Complex with AdoHcy and 15-mer Oligonucleotide Showing Semi-specific and Specific Contact

Template:ABSTRACT PUBMED 15882618

About this Structure

1YFJ is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase., Horton JR, Liebert K, Hattman S, Jeltsch A, Cheng X, Cell. 2005 May 6;121(3):349-61. PMID:15882618

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